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Metabolic analysis of schizochytrium mutants with high DHA content achieved with ARTP mutagenesis combined with iodoacetic acid and dehydroepiandrosterone screening

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By blocking TREK-1, PE-22-28: Increases neuronal excitability : Reduces potassium efflux, depolarizing neurons toward firing threshold Enhances serotonergic transmission : TREK-1 is expressed on serotonergic neurons in the dorsal raphe nucleus

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Recent studies have highlighted the substantial potential of TCM in modulating ALD, NAFLD, liver cirrhosis, and liver cancer, primarily through targeted regulation of gut microbiota (Li et al., 2019